Here, we investigated possible immunopathological effects of type I and type III interferons on adrenocortical cells in relation to AAD. We therefore hypothesize that exposure to such interferons could render the adrenal cortex susceptible to autoimmune attack in genetically predisposed individuals. Transient development of AAD and exacerbation of established or subclinical disease, as well as the induction of autoantibodies associated with AAD, have been reported following therapeutic administration of type I interferons. Type I and/or type III interferons are signature responses to virus infections, and have also been implicated in the pathogenesis of autoimmune endocrine disorders like type 1 diabetes and autoimmune thyroiditis.

As of yet, little is known about the potential role played by environmental factors in this process. In the corrosion parameters, there was a strong lipopolysaccharide correlation with the Ipass (passivation current density), Cdl (double-layer capacitance), and Rp (polarization resistance) values (pĪutoimmune Addison's disease (AAD) is caused by selective destruction of the hormone-producing cells of the adrenal cortex. The quantitative data were analyzed by Pearson's correlation and independent t-tests (α = 0.05). Their surface roughness and Vickers microhardness were also tested. The disc surfaces were characterized by scanning electron microscopy and atomic force microscopy. For the electrochemical assay, the open-circuit-potential, electrochemical impedance spectroscopy, and potentiodynamic test were used. This study evaluated the corrosion behavior of a Ti-6Al-4V alloy, with a smooth surface or conditioned by double-acid-etching, in simulated body fluid with different concentrations of dextrose and lipopolysaccharide. However, the effects of such conditions on the electrochemical stability of titanium materials remain unclear. Regulates salt, water balance, and blood pressureĬontrols key functions in the body acts as an anti-inflammatory maintains blood sugar levels, blood pressure, and muscle strength regulates salt and water balanceĪffects water retention in kidneys controls blood pressureĬontrols production of sex hormones (estrogen in women and testosterone in men) and the production of eggs in women and sperm in men.Diabetes and infections are associated with a high risk of implant failure.

Hormones of adrenal cortex